“Cannabinoid” is the collective time period for a bunch of chemical compounds that both are derived from the Hashish plant, are artificial analogues, or happen endogenously. Though cannabinoids work together largely on the stage of the at present acknowledged cannabinoid receptors, they could have cross reactivity, comparable to at opioid receptors. Sufferers with malignant illness signify a cohort inside well being care which have among the best unmet wants regardless of the provision of a plethora of guideline-driven disease-modulating therapies and ache and symptom administration choices. Cannabinoid therapies are assorted and versatile, and might be provided as prescribed drugs (nabilone, dronabinol, and nabiximols), dried botanical materials, and edible natural oils infused with cannabis extracts. Cannabinoid remedy regimens might be artistic, involving mixtures of the entire aforementioned modalities. Sufferers with malignant illness, in any respect factors of their illness trajectory, might be candidates for cannabinoid therapies whether or not as monotherapies or as adjuvants. Probably the most studied and established roles for cannabinoid therapies embrace ache, chemotherapy-induced nausea and vomiting, and anorexia. Furthermore, given their breadth of exercise, cannabinoids might be used to concurrently optimize the administration of a number of signs, thereby lowering total polypharmacy. The usage of cannabinoid therapies might be efficient in bettering high quality of life and presumably modifying malignancy by advantage of direct results and in bettering compliance or adherence with disease-modulating therapies comparable to chemotherapy and radiation remedy.