We carried out a evaluate of systematic critiques (SRs) and randomized-controlled trials (RCTs) to research efficacy and security of cannabis-based treatment in sufferers with psychological problems. 5 knowledge bases have been systematically searched (2006-August 2018); four SRs (of 11 RCTs) and 14 RCTs (1629 members) have been included. Diagnoses have been: dementia, cannabis and opioid dependence, psychoses/schizophrenia, basic social anxiousness, posttraumatic stress dysfunction, anorexia nervosa, attention-deficit hyperactivity dysfunction, and Tourette`s dysfunction. Final result variables have been too heterogeneous to conduct a meta-analysis. A story synthesis technique was utilized. The examine high quality was assessed utilizing the risk-of-bias device and SIGN-checklists. THC- and CBD-based medicines, given as adjunct to pharmaco- and psychotherapy, have been related to enhancements of a number of signs of psychological problems, however not with remission. Unintended effects occurred, however extreme hostile results have been talked about in single circumstances solely. With the intention to present dependable therapy suggestions, extra and bigger RCTs with follow-up assessments, constant end result measures and lively comparisons are wanted.