Can I Mix CBD with Nicotine?


If you currently vape nicotine based e-liquid and are starting to think about vaping CBD e-liquid for the first time, then there may undoubtedly be a few questions that you have on your mind. Can you mix CBD with nicotine? What will happen if you combine CBD vape oil with your e-liquid? Can vaping CBD help with your nicotine addiction? What are the differences between CBD and nicotine? The curious and intricate world of CBD and nicotine interaction is definitely something that vapers should know more about – let’s delve on in and find out more.

Does CBD Have Nicotine in it?

The first thing you need to know is that neither, CBD E-liquid or CBD Oil contains any nicotine. Both products primarily use CBD extracted from the legal and industrial hemp plant – the key difference is the liquid that delivers the CBD to your system. CBD oil will typically use high quality and natural olive oil, whereas, CBD Eliquid will use the natural VG liquid that is found in the nicotine-based e-liquid that you may already be familiar with.

Can I Mix CBD with E-liquid?

Similar to mixing strawberries with sugar syrup or tomatoes with treacle – yes you are able to mix CBD and e-liquid – however, in our opinion there should really be no need to and is not necessarily something that we would advise. Of course, we all have our own preferences, though our advice would be to keep it clean, keep it green and don’t mix your CBD E-liquid with your regular e-liquid because you’re just diluting the CBD.

In the case that you are thinking about mixing CBD with your e-juice, it’s of utmost importance to mix the right products. CBD Oil and CBD E-liquid are two very different products, intended for two very different purposes. It may be easier to find the right product for you before you experiment around.

As the name suggests CBD vape oil is used together with a vaporizer that has a refillable e-liquid chamber and will be the product that you will need to mix with your favourite e-juice. You can blend CBD e-liquid with either nicotine or nicotine free e-liquid, but if your reasons for mixing CBD and e juice are for flavour, then the best option would be to choose a flavoured E-liquid or a Terpene infused vape oil.


Packing a tasty punch and available in numerous flavours, these nicotine-free CBD vape oils make a great alternative to the flavoured nicotine e-juice you’re used to – with the all-important benefits of calm that CBD can provide. Quality CBD vape oil will use the best and most natural ingredients to complement the natural purity of the product, which will mean a high VG content in your CBD vape oil.

Be aware, that when you mix CBD vape oil with e-juice, your preferred e-juice may not be actually using the best ingredients, and maybe a lower quality to the CBD vape oil you’re mixing it with. As well as quality, your e-juice may be using PG liquid, which will thin the overall consistency of your final mixture. By doing this you’ll lessen the overall effect and experience that the CBD can provide you with.

The alternative to CBD E-liquid is the CBD sublingual oil, which is placed under the tongue or mixed with food and drink. Do not mix this with your e juice! The combination of CBD oil and e-liquid will leave a pretty bad taste in your mouth, not to mention clogged up coils in your vaporizer.

It’s safe to say that if you’re looking to start vaping CBD and don’t already vape nicotine, then there will definitely be no need to start your nicotine addiction now. Opt for a simple starter kit like Vapour2’s CBD Vape Kit, which will include all you need to start vaping CBD straight away.

What Happens When You Mix CBD, THC and Nicotine?

The effects of combining cannabidiol such as CBD is a subject with little if anything is known about the impact the two may have on the brain and body when absorbed together. The little research that has been conducted relates to the broader sphere of cannabis in general – which means the inclusion of the psychoactive cannabinoid THC.

Historically, much of the research that has taken place regarding cannabinoids, cannabis and the effect it has on the brain and body has largely remained the focus of pure cannabis.

According to research, “Nicotine changes marijuana’s effect on the brain” conducted by the Centre for BrainHealth, approximately 70% of those that use cannabis also use tobacco. Whilst the research and inquest into the interaction of CBD, THC and nicotine is in urgent need of address and further attention, we do know that a relationship between them exists.

But what does happen when you mix nicotine with CBD and THC? All three molecules are derived from naturally occurring plants, though the similarities do not stop there. All three molecules, together with psychoactive substances such as opioids and even caffeine are part of a complex stimulus and reward network. Similarly to the endocannabinoids systems receptors, we also have opioid and nicotinic receptors too.

The part of the brain responsible for the idea of reward and addiction is the hippocampus, which acts as a central location for many of those receptor networks to criss-cross one another. Like an underground system of roots and fungi that are intrinsically linked beneath the forest floor, these networks of receptors all correspond with one another in some way. Which way? Due to the complexity of the task at hand, time will tell how those systems interact with another. What is known is that when pure cannabis is consumed chronically, the hippocampus shrinks in size and so too does one’s memory retention. In studies relating to those who used cannabis and tobacco together, the results showed that whilst the hippocampus shrank in size, memory retention was actually increased.

Admittedly, and unsurprisingly the results mean that a thorough exploration of the subject in hand is clearly required to understand to determine the exact nature of CBD and nicotine interaction.

Can CBD Help with Nicotine Addiction?

Whilst no definitive evidence exists to suggest that CBD is a medically viable solution to reduce nicotine addiction, early research and trials show promising results for the future of those seeking to become nicotine free.

It sounds logical that the instantaneous calming effects of vaping CBD will potentially allay your cravings for nicotine as well as abating your appetite to vape something. Still smoking? Why not switch to vaping CBD and let us know how you get on?


Latest posts